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Recently, it has become possible to detect cells undergoing apoptosis in living animals. IQFCS offers an in vivo caspase detection system (FLIVO*). An injectable fluorescent probe is used to quantitate apoptosis in live animals where it specifically binds to active caspases and is trapped in the cells until analysis.

• FLIVO is a direct stain that enters the cells of living animals upon injection
• Analysis of tissues is conducted through a window chamber, fluorescent microscope or by flow cytometry.
• Unbound FLIVO reagent is removed from the cells by natural circulation


In vivo labeling of caspase-positive neurons reveals a remarkable difference in the extent of apoptotic cell death in the nucleus magnocellularis (NM) of control (left) and cochlear removal (right) from bird brains after the injection of FAM-FLIVO.

FLIVO probes are available as red sulforhodamine (SR), or green carboxyfluorescein,
(FAM) conjugates with enough reagents to test 6 or 24 mice.
• FLIVO was developed by Immunochemistry Technologies, Bloomington, MN



Griffin , R.J., Williams, B.W., Loren, M., Bischof, J.C., Olin, M., Lee, B.W., and Johnson, G. 2006. Novel use of highly specific poly-caspase inhibitor for in vivo detection of apoptosis in tumors treated with vascular targeting agents. Poster presented at the American Association for Cancer Research, April 2006.

Griffin , R., Williams, B.W., Olin, M., Lowen, M., and Song, C.W. 2005. Thermoradiotherapy enhancement with anti-vascular strategy. Poster presented at the Radiation Research Society, October 17, 2005. Morrow, T., Paulson, E. October 16, 2006. Diabetes-induced allodynia: correlation between behavioral intensity, duration of diabetes, and periaqueductal gray (PAG) activation. Poster presented at the Society for Neuroscience annual meeting, October 2006.

Olin, M., Roy , S., Peterson, P., and Moliter, T. 2006. In vivo model for the detection of morphine-induced apoptosis. Poster presented at the Society of Neuroimmunology Pharmacology (SNIP), April, 2006.

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American Qualex FLIVO6-FAM

FLIVO6-FAM kit (test size - 6 mice)

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AQ Molecular and Immunochemical